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Nic Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nicardipine  (Selleck Chemicals)
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
Nicardipine, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nicardipine  (FUJIFILM Wako Pure Chemical Co)
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
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nicardipine nitroso impurity  (Simson Pharma)
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
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nicardipine  (Thermo Fisher)
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
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nicardipine  (Nipro Pharma Corporation)
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
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intravenous nicardipine  (Preiser Scientific)
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, <t>Nicardipine,</t> Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.
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(A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, Nicardipine, Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.

Journal: Frontiers in Pharmacology

Article Title: Computational drug repurposing in Parkinson’s disease: Omaveloxolone and cyproheptadine as promising therapeutic candidates

doi: 10.3389/fphar.2025.1539032

Figure Lengend Snippet: (A) Twenty-eight PD drug candidates with neuroprotective effects. PMID stands for Specific Literature Evidence of Prior Neuroprotective Effects of the Drug. Evidence is categorized into in vivo and in vitro representations. Nine drug candidates have been shown to have neurocellular protective effects in vivo and in vitro . (B–I) CCK8 experiments validate effects of drug candidates on SH-SY5Y cells. Above are the results of testing the activity of eight drugs on MPTP-induced SH-SY5Y cells. All data are presented as mean ± SEM, n = 3. The eight drugs in order were Paliperidone, Lcz696, Nicardipine, Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen. ## P < 0.01 compared with the control group. * P < 0.05 and ** P < 0.01 compared with the MPTP group.

Article Snippet: Paliperidone, Lcz696, Nicardipine, Almitrine, Omaveloxolone, Aliskiren, Cyproheptadine and Pizotifen were purchased from Selleck (Shanghai, China), dissolved in 2% dimethyl sulfoxide (DMSO) and diluted with 0.9% saline to a stock solution.

Techniques: In Vivo, In Vitro, Activity Assay, Control